Schon mal was gehört von...

[Lava]

Yesssssssss! Gotcha! YANAGIDA heißt er und in Nature war da mal was zu lesen: NATURE | VOL 397 | 14 JANUARY 1999 | pages 129-132

A single myosin head moves along an actin filament with regular steps of 5.3 nanometres.

Kitamura K, Tokunaga M, Iwane AH, Yanagida T.

Yanagida BioMotron Project, ERATO, JST, Mino, Osaka, Japan.

Actomyosin, a complex of actin filaments and myosin motor proteins, is responsible for force generation during muscle contraction. To resolve the individual mechanical events of force generation by actomyosin, we have developed a new instrument with which we can capture and directly manipulate individual myosin subfragment-1 molecules using a scanning probe. Single subfragment-1 molecules can be visualized by using a fluorescent label. The data that we obtain using this technique are consistent with myosin moving along an actin filament with single mechanical steps of approximately 5.3 nanometres; groups of two to five rapid steps in succession often produce displacements of 11 to 30 nanometres. This multiple stepping is produced by a single myosin head during just one biochemical cycle of ATP hydrolysis.

PMID: 9923673 [PubMed - indexed for MEDLINE]

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