Auch hier: http://www.psychiatrist.com/jcp/arti.../v75s0104.aspx
sowie 2017 im Journal for Molecular Science: http://www.mdpi.com/1422-0067/18/8/1689 (man beachte das Schaubild)
findet man Material, welches zumindest die Rolle anderer Neurotransmitter in der Schizophrenie betont. So wie ich es überblicken kann, dient das dopaminerge System nur zur Beschreibung und der Therapie der Positivsymptomatik. Wenn es um die Negativsymptomatik sowie die kognitive Symptomatik geht scheinen andere Transmittersysteme sogar wichtiger. Aber vielleicht gibt's da ja unter euch noch ein paar Experten, die da besser Bescheid wissen
Um stellenweise ein paar Auszüge zu zitieren:
"Dopamine dysfunction and its treatment are not sufficient to explain the psychopathology of schizophrenia and its treatment outcomes. In addition to the devastating symptoms of psychosis, many patients with schizophrenia have cognitive impairment. These cognitive symptoms cause substantial dysfunction and can affect their ability to work, to adhere to treatment, and to apply social skills. "
"The development of antipsychotics targeting other neurotransmitters may raise the hope of addressing the frequent problem of nonadherence, which is a significant roadblock in the recovery of many patients with schizophrenia."
"Unfortunately, none of the single neurotransmitter systems could explain the full picture of the heterogeneity of schizophrenia symptoms. Intriguingly, the dopaminergic system may interact with other neurotransmitter pathways. For example, postsynaptic density has been suggested to be involved in schizophrenia, and is related to dopaminergic and glutamatergic systems [45]. The interactions between neurotransmitter systems lead to complex and diverse patterns of mechanisms potentially involved in the pathophysiology of schizophrenia [46]. Thus, the treatment strategy that exclusively targets a single neurotransmitter system is less likely to be successful."
Ich habe das IMPP auf diese Unstimmigkeiten mal hingewiesen, mal schauen was passiert. Etwas unglücklich ist die Frage allemal geraten.